The Lord's Prayer

BH3-only proteins: the lords of death.

Although the mechanisms by which Bcl-2 family proteins control the apoptotic machinery of the cell are not fully understood, it becomes clear that the role of BH3-only proteins consists in serving as sensors or sentinels of cellular damage, transducing the apoptotic stimuli to the mitochondria. For this reason, mammalian cells have developed several strategies for their strict regulation throug...

The Hospital Prayer-Books

The Efficacy of Prayer

AAA Proteins: Lords of the Ring

AAA ATPases (those associated with various cellular activities) 1 play important roles in numerous cellular activities including proteolysis, protein folding, membrane trafficking, cytoskeletal regulation, organelle biogenesis, DNA replication, and intracellular motility. Recent structural and enzymatic studies are providing clues into the properties of the conserved AAA domain that defines thi...

Debate in the House of Lords